Nickel‐Catalyzed Regio‐ and Enantioselective Ring Opening of 3,4‐Epoxy Amides and Esters with Aromatic Amines

Abstract

AbstractHerein we present a nickel‐catalyzed regio‐ and enantioselective ring opening reaction of 3,4‐epoxy amides and esters with aromatic amines as nucleophiles. This method features high regiocontrol, diastereospecific SN2 reaction pathway, broad substrate scope, and mild reaction conditions, furnishing a wide range of γ‐amino acid derivatives in a highly enantioselective manner. Notably, the selective nucleophilic attack to the C‐4 position of epoxides is controlled by the directing effect of the pendant carbonyl group.