Acetylenic Replacement of Albicidin's Methacrylamide Residue Circumvents Detrimental E / Z Photoisomerization and Preserves Antibacterial Activity

Author:

Behroz Iraj1,Kleebauer Leonardo1,Hommernick Kay1,Seidel Maria1,Grätz Stefan1,Mainz Andi1,Weston John B.1,Süssmuth Roderich D.1ORCID

Affiliation:

1. Institut für Organische Chemie Technische Universität Berlin Straße des 17. Juni 124 10623 Berlin Germany

Funder

Deutsche Forschungsgemeinschaft

Bundesministerium für Bildung und Forschung

Publisher

Wiley

Subject

General Chemistry,Catalysis,Organic Chemistry

Reference57 articles.

1. World Health Organization “Antibacterial agents in clinical development. An analysis of the antibacterial clinical development pipeline including tuberculosis” https://apps.who.int/iris/bitstream/handle/10665/258965/WHO-EMP-IAU-2017.11-eng.pdf?sequence=1(accessed June 9 2020).

2. World Health Organization “Global action plan on antimicrobial resistance” https://apps.who.int/iris/bitstream/handle/10665/193736/9789241509763 eng.pdf?sequence=1(accessed June 9 2020).

3. Resistance to polymyxins in Gram-negative organisms

4. Outer membrane permeability and antibiotic resistance

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