Overcoming AlbD Protease Resistance and Improving Potency: Synthesis and Bioactivity of Antibacterial Albicidin Analogues with Amide Bond Isosteres
Author:
Affiliation:
1. Institut für Chemie, Technische Universität Berlin, Straße des 17. Juni 124, 10623 Berlin, Germany
Funder
Deutsche Forschungsgemeinschaft
Alexander von Humboldt-Stiftung
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.1c02312
Reference24 articles.
1. Why big pharma has abandoned antibiotics
2. The antibiotic resistance crisis, with a focus on the United States
3. Preliminary Characterization of an Antibiotic Produced by Xanthomonas albilineans Which Inhibits DNA Synthesis in Escherichia coli
4. The gyrase inhibitor albicidin consists of p-aminobenzoic acids and cyanoalanine
5. Total Synthesis of Albicidin: A Lead Structure fromXanthomonas albilineansfor Potent Antibacterial Gyrase Inhibitors
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