Brain translocator protein occupancy by ONO-2952 in healthy adults: A Phase 1 PET study using [11C]PBR28-Reference-Cited by-同舟云学术

Brain translocator protein occupancy by ONO-2952 in healthy adults: A Phase 1 PET study using [11C]PBR28

Published:2017-03-11 Issue:7 Volume:71 Page:e21970
ISSN:0887-4476
Container-title:Synapse
language:en
Short-container-title:Synapse

Author:

Frankle W. Gordon¹^ORCID,Narendran Rajesh²³,Wood Andrew T.⁴,Suto Fumitaka⁵,Himes Michael L.²,Kobayashi Michiyoshi⁵,Ohno Tomoya⁵,Yamauchi Akinori⁵,Mitsui Katsukuni⁵,Duffy Kevin⁶,Bruce Mark⁶

Affiliation:

1. Department of Psychiatry; NYU Langone Medical Center; New York New York

2. Department of Psychiatry; University of Pittsburgh; Pittsburgh Pennsylvania

3. Department of Radiology; University of Pittsburgh; Pittsburgh Pennsylvania

4. Ono Pharma Inc. USA; Lawrenceville New Jersey USA

5. Ono Pharmaceutical Co. Ltd; Osaka Japan

6. Ono Pharma UK Ltd; London United Kingdom

Funder

Ono Pharmaceuticals Co., Ltd. Osaka, Japan;

Ono Pharma UK Ltd (Rachel Edwards and Jamie Ashman of Prism Ideas)

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/syn.21970/fullpdf

Reference34 articles.

1. SPECT measurement of benzodiazepine receptors in human brain with iodine-123-iomazenil: Kinetic and equilibrium paradigms;Abi-Dargham;Journal of Nuclear Medicine,1994

2. Prefrontal dopamine D1 receptors and working memory in schizophrenia;Abi-Dargham;Journal of Neuroscience,2002

3. Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states;Batarseh;Molecular and Cellular Endocrinology,2010

4. Synthesis and evaluation in monkey of two sensitive 11C-labeled aryloxyanilide ligands for imaging brain peripheral benzodiazepine receptors in vivo;Briard;Journal of Medicinal Chemistry,2008

5. Translocator protein 18 kDa (TSPO): Molecular sensor of brain injury and repair;Chen;Pharmacology Therapeutics,2008

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Imaging the Influence of Red Blood Cell Docosahexaenoic Acid Status on the Expression of the 18 kDa Translocator Protein in the Brain: A [11C]PBR28 Positron Emission Tomography Study in Young Healthy Men;Biological Psychiatry: Cognitive Neuroscience and Neuroimaging;2021-10

2. In Vivo Receptor Visualization and Evaluation of Receptor Occupancy with Positron Emission Tomography;Journal of Medicinal Chemistry;2021-04-27

3. Translocator protein in late stage Alzheimer’s disease and Dementia with Lewy bodies brains;Annals of Clinical and Translational Neurology;2019-07-09

4. Unbinding of Translocator Protein 18 kDa (TSPO) Ligands: From in Vitro Residence Time to in Vivo Efficacy via in Silico Simulations;ACS Chemical Neuroscience;2019-06-21

5. Concentration, distribution, and influence of aging on the 18 kDa translocator protein in human brain: Implications for brain imaging studies;Journal of Cerebral Blood Flow & Metabolism;2019-06-20