Systematic Interpolation Method Predicts Antibody Monomer-Dimer Separation by Gradient Elution Chromatography at High Protein Loads
Author:
Affiliation:
1. Department of Chemical Engineering; University of Virginia; 102 Engineers’ Way Charlottesville Virginia 22904 USA
2. MedImmune; Gaithersburg Maryland USA
3. Biologics Process Development; Bristol-Myers Squibb; Hopewell New Jersey USA
Publisher
Wiley
Subject
Molecular Medicine,Applied Microbiology and Biotechnology,General Medicine
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/biot.201800132/fullpdf
Reference35 articles.
1. The Immunogenicity of Antibody Aggregates in a Novel Transgenic Mouse Model
2. In Vivo Effect of Innate Immune Response Modulating Impurities on the Skin Milieu Using a Macaque Model: Impact on Product Immunogenicity
3. Multiproduct High-Resolution Monoclonal Antibody Charge Variant Separations by pH Gradient Ion-Exchange Chromatography
4. Charge heterogeneity profiling of monoclonal antibodies using low ionic strength ion-exchange chromatography and well-controlled pH gradients on monolithic columns
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