The Immunogenicity of Antibody Aggregates in a Novel Transgenic Mouse Model

Author:

Bessa Juliana,Boeckle Sabine,Beck Hermann,Buckel Thomas,Schlicht Sonja,Ebeling Martin,Kiialainen Anna,Koulov Atanas,Boll Björn,Weiser Thomas,Singer Thomas,Rolink Antonius G.,Iglesias Antonio

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Organic Chemistry,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biotechnology

Reference62 articles.

1. Beck A, Wurch T, Bailly C, Corvaia N. Strategies and challenges for the next generation of therapeutic antibodies. Nat Rev. 2010;10:345–52.

2. Reichert JM. Antibodies to watch in 2010. mAbs. 2010;2:84–100.

3. Ryffand JC, Schellekens H. Immunogenicity of rDNA-derived pharmaceuticals. Trends Pharmacol Sci. 2002;23:254–6.

4. Pendley C, Schantz A, Wagner C. Immunogenicity of therapeutic monoclonal antibodies. Curr Opin Mol Ther. 2003;5:172–9.

5. Baker MP, Reynolds HM, Lumicisi B, Bryson CJ. Immunogenicity of protein therapeutics: the key causes, consequences and challenges. Self Nonself. 2010;1:314–22.

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