Elucidating the Impact of CHO Cell Culture Media on Tryptophan Oxidation of a Monoclonal Antibody Through Gene Expression Analyses-Reference-Cited by-同舟云学术

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Elucidating the Impact of CHO Cell Culture Media on Tryptophan Oxidation of a Monoclonal Antibody Through Gene Expression Analyses

Published:2018-04-17 Issue:10 Volume:13 Page:1700254
ISSN:1860-6768
Container-title:Biotechnology Journal
language:en
Short-container-title:Biotechnol. J.

Author:

He Luhong¹,Desai Jairav X.²,Gao Jinxin³,Hazeltine Laurie B.¹,Lian Zhirui¹,Calley John N.⁴,Frye Christopher C.¹

Affiliation:

1. Bioprocess Research and Development, Eli Lilly and Company; Indianapolis 46285 IN USA

2. Informatics Capabilities − Research IT, Eli Lilly and Company; Indianapolis 46285 IN USA

3. Statistics- Discovery/Development, Eli Lilly and Company; Indianapolis 46285 IN USA

4. Tailored Therapeutics Bioinformatics, Eli Lilly and Company; Indianapolis 46285 IN USA

Publisher

Wiley

Subject

Molecular Medicine,Applied Microbiology and Biotechnology,General Medicine

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/biot.201700254/fullpdf

Reference52 articles.

1. Antibodies to watch in 2017

2. Post-translational Modifications of Recombinant Proteins: Significance for Biopharmaceuticals

3. A novel approach to investigate the effect of methionine oxidation on pharmacokinetic properties of therapeutic antibodies

4. Oxidation of Therapeutic Proteins and Peptides: Structural and Biological Consequences

5. Oxidative degradation of pharmaceuticals: Theory, mechanisms and inhibition

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