Untargeted metabolomics analysis reveals spatial metabolic heterogeneity in different intestinal segments of type 1 diabetic mice-Reference-Cited by-同舟云学术

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Untargeted metabolomics analysis reveals spatial metabolic heterogeneity in different intestinal segments of type 1 diabetic mice

Published:2024 Issue: Volume: Page:
ISSN:2515-4184
Container-title:Molecular Omics
language:en
Short-container-title:Mol. Omics

Author:

Gong Kaiyan¹,Chen Junli¹,Yin Xiaoli¹,Wu Mengjun¹,Zheng Hong¹^ORCID,Jiang Lingling²³

Affiliation:

1. School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China

2. College of Science and Technology, Wenzhou-Kean University, Wenzhou 325060, China

3. Wenzhou Municipal Key Laboratory for Applied Biomedical and Biopharmaceutical Informatics, Wenzhou-Kean University, Wenzhou 325060, China

Abstract

Untargeted metabolomics reveals intestinal segment-specific metabolic disorders of type 1 diabetic mice. Amino acid metabolism was disrupted mainly in the jejunum, whereas fatty acid metabolism mainly in the ileum, cecum and colon.

Funder

Wenzhou-Kean University

Publisher

Royal Society of Chemistry (RSC)

Subject

Genetics,Molecular Biology,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MO/D3MO00163F

Reference68 articles.

1. Type 1 diabetes

2. Apolipoprotein CIII Is an Important Piece in the Type-1 Diabetes Jigsaw Puzzle

3. Gastrointestinal Complications of Diabetes

4. Diabetic Enteropathy: From Molecule to Mechanism-Based Treatment

5. Gastric Emptying Abnormalities in Diabetes Mellitus

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