Low glucose depletes glycan precursors, reduces site occupancy and galactosylation of a monoclonal antibody in CHO cell culture-Reference-Cited by-同舟云学术

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Low glucose depletes glycan precursors, reduces site occupancy and galactosylation of a monoclonal antibody in CHO cell culture

Published:2015-06-24 Issue:7 Volume:10 Page:1051-1066
ISSN:1860-6768
Container-title:Biotechnology Journal
language:en
Short-container-title:Biotechnology Journal

Author:

Villacrés Carina,Tayi Venkata S.,Lattová Erika,Perreault Hélène,Butler Michael

Funder

Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada

Publisher

Wiley

Subject

Molecular Medicine,Applied Microbiology and Biotechnology,General Medicine

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/biot.201400662/fullpdf

Reference70 articles.

1. The impact of glycosylation on the biological function and structure of human immunoglobulins.;Arnold;Annu. Rev. Immunol.,2007

2. Structure and function of immunoglobulins.;Schroeder;J. Allergy Clin. Immunol.,2010

3. The role of constant region carbohydrate in the assembly and secretion of human IgD and IgA1.;Gala;J. Biol. Chem.,2002

4. Impact of glycosylation on effector functions of therapeutic IgG.;Abès;Pharmaceuticals,2010

5. Improvement of interferon-gamma sialylation in Chinese hamster ovary cell culture by feeding of N-acetylmannosamine.;Gu;Biotechnol. Bioeng.,1998

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