Drug screening in 3D in vitro tumor models: overcoming current pitfalls of efficacy read-outs
Author:
Affiliation:
1. iBET; Instituto de Biologia Experimental e Tecnológica; Oeiras Portugal
2. Instituto de Tecnologia Química e Biológica António Xavier; Universidade Nova de Lisboa; Oeiras Portugal
3. Abbvie; North Chicago IL USA
Funder
Seventh Framework Programme
Ministério da Ciência e Tecnologia
Federación Española de Enfermedades Raras
Publisher
Wiley
Subject
Molecular Medicine,Applied Microbiology and Biotechnology,General Medicine
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3. Modeling human carcinomas: Physiologically relevant 3D models to improve anti-cancer drug development;Unger;Advanced Drug Delivery Rev.,2014
4. High-content phenotypic profiling of drug response signatures across distinct cancer cells;Caie;Mol. Cancer Ther.,2010
5. et al., 3D tumor spheroid models for in vitro therapeutic screening: A systematic approach to enhance the biological relevance of data obtained;Zanoni;Sci. Rep.,2016
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