Centromeric breakage and highly rearranged chromosome derivatives associated with mutations ofTP53 are common in therapy-related MDS and AML after therapy with alkylating agents: An M-FISH study
Author:
Publisher
Wiley
Subject
Cancer Research,Genetics
Reference43 articles.
1. Increased frequency of dicentric chromosomes in therapy-related MDS and AML compared to de novo disease is significantly related to previous treatment with alkylating agents and suggests a specific susceptibility to chromosome breakage at the centromere
2. Duplication or amplification of chromosome band 11q23, including the unrearrangedMLL gene, is a recurrent abnormality in therapy-related MDS and AML, and is closely related to mutation of theTP53 gene and to previous therapy with alkylating agents
3. Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461)
4. Mutations With Loss of Heterozygosity of p53 Are Common in Therapy-Related Myelodysplasia and Acute Myeloid Leukemia After Exposure to Alkylating Agents and Significantly Associated With Deletion or Loss of 5q, a Complex Karyotype, and a Poor Prognosis
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