Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/− ) mice

Author:

Moncsek Anja1,Al-Suraih Mohammed S.2,Trussoni Christy E.2,O'Hara Steven P.2,Splinter Patrick L.2,Zuber Camille1,Patsenker Eleonora1,Valli Piero V.1,Fingas Christian D.3,Weber Achim4,Zhu Yi5,Tchkonia Tamar5,Kirkland James L.5,Gores Gregory J.2,Müllhaupt Beat1,LaRusso Nicholas F.2,Mertens Joachim C.1

Affiliation:

1. Department of Gastroenterology and Hepatology; University Hospital Zürich; Zürich Switzerland

2. Division of Gastroenterology and Hepatology and Center for Cell Signaling in Gastroenterology; Mayo Clinic; Rochester MN

3. Department of General, Visceral, and Transplantation Surgery; University Hospital Essen; Essen Germany

4. Department of Pathology and Molecular Pathology; University Hospital Zürich; Zürich Switzerland

5. The Robert and Arlene Kogod Center on Aging; Mayo Clinic; Rochester MN

Funder

Swiss National Science Foundation

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute on Aging

Connor Group

Noaber and Glenn Foundations

National Institutes of Health

University of Zürich (Forschungskredit)

Max and Martha Dangel Foundation

Stiftung zur Krebsbekämpfung

Publisher

Wiley

Subject

Hepatology

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