Further Exploration of the Benzimidazole Scaffold as TRPC5 Inhibitors: Identification of 1‐Alkyl‐2‐(pyrrolidin‐1‐yl)‐1 <i>H</i> ‐benzo[ <i>d</i> ]imidazoles as Potent and Selective Inhibitors-Reference-Cited by-同舟云学术

Further Exploration of the Benzimidazole Scaffold as TRPC5 Inhibitors: Identification of 1‐Alkyl‐2‐(pyrrolidin‐1‐yl)‐1 H ‐benzo[ d ]imidazoles as Potent and Selective Inhibitors

Published:2022-05-24 Issue:14 Volume:17 Page:
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Sharma Swagat¹,L. Pablo Juan²³,Tolentino Kirsten T.¹,Gallegos Wacey¹,Hinman Jennifer¹,Beninato Madison¹⁴,Asche MacKenzie¹⁴,Greka Anna²³,Hopkins Corey R.¹^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences University of Nebraska Medical Center Omaha NE 68198 USA

2. Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston MA 02115 USA

3. Broad Institute of MIT and Harvard Cambridge MA 02142 USA

4. High School Alliance University of Nebraska Medical Center Omaha NE 68198 USA

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202200151

Reference21 articles.

1. TRP channels as cellular sensors

2. The TRP Channels, a Remarkably Functional Family

3. Structure of the receptor-activated human TRPC6 and TRPC3 ion channels

4. Structure of the mouse TRPC4 ion channel

5. Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function

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