Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function

Author:

Duan Jingjing123ORCID,Li Jian45ORCID,Chen Gui-Lan67ORCID,Ge Yan6,Liu Jieyu6,Xie Kechen6,Peng Xiaogang8,Zhou Wei8,Zhong Jianing5ORCID,Zhang Yixing2,Xu Jie9,Xue Changhu9,Liang Bo10ORCID,Zhu Lan11ORCID,Liu Wei11,Zhang Cheng12,Tian Xiao-Li1ORCID,Wang Jianbin2,Clapham David E.3ORCID,Zeng Bo67ORCID,Li Zongli13ORCID,Zhang Jin2ORCID

Affiliation:

1. Human Aging Research Institute (HARI), School of Life Sciences, Nanchang University, Nanchang, Jiangxi 330031, China.

2. School of Basic Medical Sciences, Nanchang University, Nanchang, Jiangxi 330031, China.

3. Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.

4. Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of the Ministry of Education, Gannan Medical University, Ganzhou 341000, China.

5. College of Pharmaceutical Sciences, Gannan Medical University, #1 Yixueyuan Road, Ganzhou, Jiangxi 341000, China.

6. Key Laboratory of Medical Electrophysiology, Ministry of Education and Sichuan Province and Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan 646000, China.

7. Department of Endocrinology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China.

8. Key Laboratory of Molecular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.

9. College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.

10. Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.

11. School of Molecular Sciences and Biodesign Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.

12. Jiangxi Jmerry Biopharmaceutical Co. Ltd, Ganzhou, Jiangxi 341000, China.

13. Howard Hughes Medical Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Research reveals the structure of the TRPC5 ion channel, a potential drug target of kidney disease, depression and anxiety.

Funder

National Natural Science Foundation of China

Thousand Young Talents Program of China

Jiangxi Province Natural Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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