Getting a Grip on the Undrugged: Targeting β‐Catenin with Fragment‐Based Methods-Reference-Cited by-同舟云学术

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Getting a Grip on the Undrugged: Targeting β‐Catenin with Fragment‐Based Methods

Published:2021-01-14 Issue:9 Volume:16 Page:1420-1424
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Kessler Dirk¹^ORCID,Mayer Moriz¹,Zahn Stephan K.¹,Zeeb Markus²,Wöhrle Simon¹^ORCID,Bergner Andreas¹^ORCID,Bruchhaus Jens¹,Ciftci Tuncay²,Dahmann Georg²,Dettling Maike¹,Döbel Sandra¹,Fuchs Julian E.¹^ORCID,Geist Leonhard¹^ORCID,Hela Wolfgang¹,Kofink Christiane¹^ORCID,Kousek Roland¹,Moser Franziska²,Puchner Teresa¹,Rumpel Klaus¹,Scharnweber Maximilian¹,Werni Patrick¹,Wolkerstorfer Bernhard¹,Breitsprecher Dennis³⁴,Baaske Philipp³,Pearson Mark¹,McConnell Darryl B.¹^ORCID,Böttcher Jark¹^ORCID

Affiliation:

1. Boehringer Ingelheim RCV GmbH & Co KG Dr.-Boehringer-Gasse 5–11 1121 Vienna Austria

2. Boehringer Ingelheim Pharma GmbH & Co KG Birkendorfer Straße 65 88397 Biberach Germany

3. NanoTemper Technologies GmbH Floessergasse 4 81369 Muenchen Germany

4. Leica Microsystems AG Max Schmidheiny-Strasse 201 9435 Heerbrugg Switzerland

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202000839

Reference33 articles.

1. Oncogenic Signaling Pathways in The Cancer Genome Atlas

2. Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism

3. β-catenin is a target for the ubiquitin–proteasome pathway

4. Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon Carcinoma

5. The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates

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2. Simplified Synthesis of Renieramycin T Derivatives to Target Cancer Stem Cells via β-Catenin Proteasomal Degradation in Human Lung Cancer;Marine Drugs;2023-11-30

3. Using ultra-performance liquid chromatography with linear ion trap-electrostatic field orbitrap mass spectrometry, network pharmacology, and molecular docking to explore the constituent targets and action mechanisms of decoction of Angelica sinensis, Zingiberis Rhizoma Recens, and Mutton in the treatment of diarrhea-predominant irritable bowel syndrome;Journal of Pharmacy and Pharmacology;2023-10-13

4. Novel N-(Heterocyclylphenyl)benzensulfonamide Sharing an Unreported Binding Site with T-Cell Factor 4 at the β-Catenin Armadillo Repeats Domain as an Anticancer Agent;ACS Pharmacology & Translational Science;2023-07-03

5. Sesquiterpene Coumarin Ethers with Selective Cytotoxic Activities from the Roots of Ferula huber-morathii Peşmen (Apiaceae) and Unequivocal Determination of the Absolute Stereochemistry of Samarcandin;Pharmaceuticals;2023-05-26

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