Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as Pf eEF2

Author:

Laleu Benoît1,Rubiano Kelly23,Yeo Tomas2,Hallyburton Irene4,Anderson Mark4,Crespo‐Fernandez Benigno5,Gamo Francisco‐Javier5,Antonova‐Koch Yevgeniya67,Orjuela‐Sanchez Pamela68,Wittlin Sergio910,Jana Gouranga P.11,Maity Bikash C.11,Chenu Elodie1,Duffy James1,Sjö Peter1,Waterson David1,Winzeler Elizabeth6,Guantai Eric12,Fidock David A.213,Hansson Thomas G.1ORCID

Affiliation:

1. Medicines for Malaria Venture International Centre Cointrin Route de Pré-Bois 20, P.O. Box 1826 1215 Geneva 15 Switzerland

2. Department of Microbiology & Immunology Columbia University Irving Medical Center New York, NY 10032 USA

3. Current address Department of Molecular Microbiology Washington University School of Medicine Saint Louis MO 63110 USA

4. Drug Discovery Unit Wellcome Centre for Anti-infective Research University of Dundee Dow Street Dundee DD1 5EH UK

5. Global Health GlaxoSmithKline R&D Tres Cantos 28760 Madrid Spain

6. Department of Pediatrics School of Medicine University of California San Diego La Jolla CA 92093 USA

7. Current address Calibr A Division of Scripps Research 11119 North Torrey Pines Road La Jola CA 92037 USA

8. Current address Novartis Institute for Tropical Diseases 5959 Horton Street, 8th floor Emeryville CS 94608 USA

9. Swiss Tropical and Public Health Institute Socinstrasse 57 4002 Basel Switzerland

10. University of Basel 4002 Basel Switzerland

11. TCG Lifesciences Private Limited Block BN, Plot 7 Salt-lake Electronics Complex, Sector V Kolkata 700091 West Bengal India

12. Department of Pharmacy Faculty of Health Sciences University of Nairobi 00202- Nairobi Kenya

13. Division of Infectious Diseases Department of Medicine Columbia University Irving Medical Center New York, NY 10032 USA

Funder

World Health Organization

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

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