Synthesis of CF3, CF2H‐Substituted, Epoxide‐Fused Heterocycles with Prop‐2‐ynylsulfonium salts

Abstract

AbstractThe synthesis CF3, CF2H‐Substituted, epoxide‐fused heterocycles was performed efficiently using [4+2]/[2+1]‐annulation of ortho‐amino trifluoracetophenone or difluoroacetophenone derivatives and prop‐2‐ynylsulfonium salts. This resulted in a wide range of target compounds with various substituents and functionalities in moderate to good yields. The transformation makes it an alternative method to previous protocols. Moreover, the successful synthesis finds application in pharmaceutical and biomedical of the investigated compounds, which are expected to develop further.