Structure‐Based Virtual Screening and <i>in vitro</i> and <i>in vivo</i> Analyses Revealed Potent Methyltransferase G9a Inhibitors as Prospective Anti‐Alzheimer's Agents-Reference-Cited by-同舟云学术

Structure‐Based Virtual Screening and in vitro and in vivo Analyses Revealed Potent Methyltransferase G9a Inhibitors as Prospective Anti‐Alzheimer's Agents

Published:2022-05-19 Issue:13 Volume:17 Page:
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Bellver‐Sanchis Aina¹^ORCID,Singh Choudhary Bhanwar²³^ORCID,Companys‐Alemany Júlia¹^ORCID,Sukanya ²^ORCID,Ávila‐López Pedro A.⁴^ORCID,Martínez Rodríguez Antón Leandro⁵,Brea Floriani Jose Manuel⁵,Malik Ruchi²^ORCID,Pallàs Mercè¹^ORCID,Pérez Belén⁶^ORCID,Griñán‐Ferré Christian¹^ORCID

Affiliation:

1. Pharmacology Section Department of Pharmacology Toxicology and Therapeutic Chemistry Faculty of Pharmacy and Food Sciences Institute of Neuroscience, Universitat de Barcelona (NeuroUB) Av. Joan XXIII 27–31 08028 Barcelona Spain

2. Department of Pharmacy Central University of Rajasthan Bandarsindari Ajmer 305817 India

3. Department of Pharmaceutical Chemistry and Quality Assurance Shree S. K. Patel College of Pharmaceutical Education and Research Ganpat University Mehsana Gujarat 384012 India

4. Department of Biochemistry and Molecular Genetics Feinberg School of Medicine Northwestern University Chicago Illinois USA

5. Centro de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS) Departamento de Farmacología Farmacia y Tecnología Farmacéutica Universidad de Santiago de Compostela 15782 Santiago de Compostela Spain

6. Department of Pharmacology, Therapeutic and Toxicology Universitat Autònoma de Barcelona 08193 Barcelona Spain

Funder

Ministerio de Economía y Competitividad

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202200002

Reference40 articles.

1. Epigenetic modifications of histones in cancer

2. Epigenetics and addiction

3. Epigenetic Regulation in Neurodegenerative Diseases

4. Epigenetic modifications and human disease

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