Design, Synthesis, and Characterization of Novel CXCR4 Antagonists Featuring Cyclic Amines-Reference-Cited by-同舟云学术

Design, Synthesis, and Characterization of Novel CXCR4 Antagonists Featuring Cyclic Amines

Published:2020-05-29 Issue:13 Volume:15 Page:1150-1162
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Lin Yu¹,Li Zhanhui¹,Ma Haikuo¹²,Wang Yujie¹,Wang Xu¹,Song Shiwei¹,Zhao Li¹,Wu Shuwei¹,Tian Sheng¹,Fu Chunyan³,Luo Lusong³,Zhu Fang²⁴,He Sudan²⁴,Zheng Jiyue¹,Zhang Xiaohu¹^ORCID

Affiliation:

1. Jiangsu Key Laboratory of Neuropsychiatric DiseasesCollege of Pharmaceutical SciencesSoochow University Suzhou Jiangsu 215123 P. R. China

2. Jiangsu Institute of HematologyCollaborative Innovation Center of HematologySoochow University Suzhou 215123 P. R. China

3. BeiGene (Beijing) Co., Ltd. No. 30 Science Park Road, Zhongguancun Life Science Park Beijing 102206 P. R. China

4. Center of Systems MedicineInstitute of Basic Medical SciencesChinese Academy of Medical Sciences & Peking Union Medial College, BeijingSuzhou Institute of Systems Medicine Suzhou 215123 Jiangsu P. R. China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202000268

Reference31 articles.

1. Entry inhibitors and their use in the treatment of HIV-1 infection

2. Discovery of non-peptide small molecular CXCR4 antagonists as anti-HIV agents: Recent advances and future opportunities

3. The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2mnull mice