A simple method for <i>N</i>-arylation of secondary amides/amines through a NaH-initiated aryne generation strategy-Reference-Cited by-同舟云学术

A simple method for N-arylation of secondary amides/amines through a NaH-initiated aryne generation strategy

Published:2024 Issue:1 Volume:11 Page:12-20
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Jiang Yuanrui¹,Zhu Wenjing¹,Huang Jiawen¹,Luo Fan²,Chen Xiaobei³,Fang Chunhui¹,Chen Xin¹,Liu Shihui²^ORCID,Hu Yanwei¹,Zhang Shilei¹^ORCID

Affiliation:

1. Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, 199 Ren'ai Road, Suzhou, Jiangsu, 215123, P. R. China

2. College of Medicine, Jiaxing University, 118 Jiahang Road, Jiaxing 314001, P. R. China

3. Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, and State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science & Technology, Shanghai, 200237, P. R. China

Abstract

A very simple and practical method has been uncovered for N-arylation of many sets of secondary amides/amines.

Funder

National Natural Science Foundation of China

East China University of Science and Technology

Priority Academic Program Development of Jiangsu Higher Education Institutions

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D3QO01109G