Structure‐Activity Relationship Explorations and Discovery of a Potent Antagonist for the Free Fatty Acid Receptor 2-Reference-Cited by-同舟云学术

Structure‐Activity Relationship Explorations and Discovery of a Potent Antagonist for the Free Fatty Acid Receptor 2

Published:2021-09-12 Issue:21 Volume:16 Page:3326-3341
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Højgaard Hansen Anders¹,Christensen Henriette B.¹,Pandey Sunil K.¹,Sergeev Eugenia²,Valentini Alice³,Dunlop Julia²,Dedeo Domonkos²,Fratta Simone³,Hudson Brian D.²,Milligan Graeme²,Ulven Trond³¹,Rexen Ulven Elisabeth³

Affiliation:

1. Department of Physics Chemistry and Pharmacy University of Southern Denmark Campusvej 55 5230 Odense M Denmark

2. Centre for Translational Pharmacology Institute of Molecular Cell and Systems Biology College of Medical Veterinary and Life Sciences University of Glasgow Glasgow G12 8QQ Scotland UK

3. Department of Drug Design and Pharmacology University of Copenhagen Universitetsparken 2 2100 Copenhagen Denmark

Funder

Strategiske Forskningsråd

Lundbeckfonden

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202100356

Reference58 articles.

2. The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids

3. Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell Activation

4. Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids

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