Discovery of Potent Tetrazole Free Fatty Acid Receptor 2 Antagonists-Reference-Cited by-同舟云学术

Discovery of Potent Tetrazole Free Fatty Acid Receptor 2 Antagonists

Published:2023-05-02 Issue:9 Volume:66 Page:6105-6121
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Valentini Alice¹,Schultz-Knudsen Katrine¹,Højgaard Hansen Anders²,Tsakoumagkou Argyro¹,Jenkins Laura³,Christensen Henriette B.²,Manandhar Asmita¹,Milligan Graeme³^ORCID,Ulven Trond¹²^ORCID,Rexen Ulven Elisabeth¹^ORCID

Affiliation:

1. Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark

2. Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark

3. Centre for Translational Pharmacology, School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom

Funder

Novo Nordisk Fonden

Innovationsfonden

Biotechnology and Biological Sciences Research Council

Lundbeckfonden

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01935

Reference58 articles.

1. From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

2. Metabolite-Sensing G Protein–Coupled Receptors—Facilitators of Diet-Related Immune Regulation

3. Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids

4. The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids

5. Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell Activation

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