Adenine Modification at C7 as a Viable Strategy to Potentiate the Antimalarial Activity of Quinolones

Author:

Kurian Jais1,Kumari Varsha23,Chaluvalappil Saheer V.4,Anas Mohammad2,Manhas Ashan2,Kalluruttimmal Ramshad1,Kumar Niti23,Manheri Muraleedharan K.1ORCID

Affiliation:

1. Department of Chemistry Indian Institute of Technology Madras Chennai 600036 Tamil Nadu India

2. Department of Molecular Microbiology and Immunology CSIR-Central Drug Research Institute Sector 10, Jankipuram extension, Sitapur road Lucknow 226031 India

3. Academy of Scientific and Innovative Research (AcSIR) Ghaziabad 201002 India

4. Department of Chemistry Krishna Menon Memorial Government Women's College Kannur 670004 Kerala India

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference53 articles.

1. World Malaria Report 2019 (https://www.who.int/publications/i/item/world-malaria-report-2019).

2. Guidelines for the treatment of malaria Third edition (https://www.who.int/docs/default-source/documents/publications/gmp/guidelines-for-the-treatment-of-malaria-eng.pdfsfvrsn=a0138b77_2).

3. The past, present and future of anti-malarial medicines

4. ICI 56,780 Optimization: Structure–Activity Relationship Studies of 7-(2-Phenoxyethoxy)-4(1H)-quinolones with Antimalarial Activity

5. In Vitro Activities of 25 Quinolones and Fluoroquinolones against Liver and Blood Stage Plasmodium spp

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