No developmental toxicity observed with dolutegravir in rat whole embryo culture-Reference-Cited by-同舟云学术

No developmental toxicity observed with dolutegravir in rat whole embryo culture

Published:2021-08-28 Issue:16 Volume:113 Page:1190-1197
ISSN:2472-1727
Container-title:Birth Defects Research
language:en
Short-container-title:Birth Defects Research

Author:

Posobiec Lorraine M.¹^ORCID,Chapman Sharon P.¹,Murzyn Stacia F.¹,Rendemonti Joyce E.¹,Stanislaus Dinesh J.²,Romach Elizabeth H.³

Affiliation:

1. Department of Reproductive Toxicology GlaxoSmithKline USA Collegeville Pennsylvania USA

2. Department of Safety Assessment GlaxoSmithKline USA Philadelphia Pennsylvania USA

3. ViiV Healthcare US Research Triangle Park North Carolina USA

Publisher

Wiley

Subject

Health, Toxicology and Mutagenesis,Developmental Biology,Toxicology,Embryology,Pediatrics, Perinatology, and Child Health

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bdr2.1949

Reference14 articles.

1. Quantitation of rat embryonic development in vitro: A morphological scoring system

2. Staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope

3. ICH Guidance S5 R3. (2020).Detection of reproductive and developmental toxicity for human pharmaceuticals. Retrieved fromhttps://www.ich.org/page/safety-guidlines

4. Dolutegravir in pregnant mice is associated with increased rates of fetal defects at therapeutic but not at supratherapeutic levels

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