1. Department of Medicinal and Applied Chemistry Kaohsiung Medical University Kaohsiung 80708 Taiwan, ROC
2. Department of Chemistry Keio University 108-8345 Tokyo Japan
3. Department of Medical Research Kaohsiung Medical University Hospital Kaohsiung 80708 Taiwan, ROC
4. Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung 80708 Taiwan, ROC