Catalyst-free activation of N–C(O) Amide bonds – efficient cascade synthesis of <i>N</i>-acyl thiocarbamides in batch and continuous-flow-Reference-Cited by-同舟云学术

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Catalyst-free activation of N–C(O) Amide bonds – efficient cascade synthesis of N-acyl thiocarbamides in batch and continuous-flow

Published:2024 Issue:9 Volume:26 Page:5187-5193
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Govindan Karthick¹^ORCID,Chen Nian-Qi¹^ORCID,Lin Wei-Yu¹²³^ORCID

Affiliation:

1. Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 80708, Taiwan, Republic of China

2. Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan, Republic of China

3. Drug Development and Value Creation Research Centre, Kaohsiung Medical University, Taiwan, Republic of China

Abstract

We developed, a sustainable approach for the direct synthesis of activated amides (N-acyl saccharin) into divergent thiocarbamide derivatives using thiocyanate salts and 2-MeTHF as a green solvent.

Funder

National Science and Technology Council

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/GC/D4GC00518J

Reference64 articles.

1. Synthesis and structural analysis of 2-quinuclidonium tetrafluoroborate

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3. Amide Bond Formation Strategies: Latest Advances on a Dateless Transformation

4. L.Pauling , The nature of the chemical bond , Ithaca, New York , 1960

5. Strong Bonds Made Weak: Towards the General Utility of Amides as Synthetic Modules

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