Pharmacokinetics and Safety of Glasdegib in Participants With Moderate/Severe Hepatic Impairment: A Phase I, Single‐Dose, Matched Case‐Control Study
Author:
Affiliation:
1. Pharmacometrics Pfizer Inc La Jolla California USA
2. Clinical Statistics Pfizer Inc Groton Connecticut USA
3. Pharmacometrics Pfizer Inc Groton Connecticut USA
4. Clinical Pharmacology Pfizer Inc La Jolla California USA
Publisher
Wiley
Subject
Pharmacology (medical),Pharmaceutical Science
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpdd.897
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1. Acute Myeloid Leukemia
2. Hedgehog signaling inhibitors in solid and hematological cancers
3. Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened
4. Glasdegib: First Global Approval
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1. Update on glasdegib in acute myeloid leukemia – broadening horizons of Hedgehog pathway inhibitors;Acta Pharmaceutica;2021-08-30
2. A review of the evidence base for utilizing Child-Pugh criteria for guiding dosing of anticancer drugs in patients with cancer and liver impairment;ESMO Open;2021-06
3. Exposure–response modeling of the effect of glasdegib on cardiac repolarization in patients with cancer;Expert Review of Clinical Pharmacology;2021-05-18
4. Selection and management of older patients with acute myeloid leukemia treated with glasdegib plus low-dose cytarabine: expert panel review;Leukemia & Lymphoma;2020-09-24
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