Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened-Reference-Cited by-同舟云学术

Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened

Published:2011-12-21 Issue:2 Volume:3 Page:106-111
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Munchhof Michael J.¹,Li Qifang²,Shavnya Andrei²,Borzillo Gary V.²,Boyden Tracey L.²,Jones Christopher S.³,LaGreca Susan D.⁴,Martinez-Alsina Luis²,Patel Nandini²,Pelletier Kathleen²,Reiter Larry A.⁵,Robbins Michael D.⁶,Tkalcevic George T.²

Affiliation:

1. Michael J. Munchhof LLC, 266 West Road, Salem, Connecticut 06420, United States

2. Pfizer Global Research and Development, Groton, Connecticut 06340, United States

3. 24 Queen Eleanor Drive, Gales Ferry, Connecticut 06335, United States

4. INC Research, Old Lyme, Connecticut 06371, United States

5. Reiter.MedChem, 32 West Mystic Avenue, Mystic, Connecticut 06355, United States

6. Bristol-Meyers Squibb, Princeton, New Jersey 08540, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml2002423

Reference16 articles.

1. Modulators of the hedgehog signaling pathway

2. Targeting the Hedgehog pathway in cancer

3. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

4. Chemical Compounds of Veratrum calif ornicum Related to Congenital Ovine Cyclopian Malformations: Extraction of Active Material.

5. Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

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