Chiral control of enantiomers through crystallization: Moving from ternary phase diagrams to design spaces
Author:
Affiliation:
1. Pivotal Drug Substance Process Development, Amgen Inc.; Thousand Oaks CA 91320
Publisher
Wiley
Subject
General Chemical Engineering,Environmental Engineering,Biotechnology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/aic.16202/fullpdf
Reference18 articles.
1. ICH Q6A Guideline Specifications 1999 http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Quality/Q6A/Step4/Q6Astep4.pdf
2. Application of continuous preferential crystallization to efficiently access enantiopure chemicals;Rougeot;Org Process Res Dev.,2015
3. Processes to separate enantiomers;Lorenz;Angew Chem Int Ed.,2014
4. Separation of conglomerate forming enantiomers using a novel continuous preferential crystallization process;Vetter;AIChE J.,2015
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