Axial Chirality in the Sotorasib Drug Substance, Part 1: Development of a Classical Resolution to Prepare an Atropisomerically Pure Sotorasib Intermediate
Author:
Affiliation:
1. Amgen, Inc., 360 Binney Street, Cambridge, Massachusetts 02142, United States
2. Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.2c00176
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1. The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity
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5. Using the Right Green Yardstick: Why Process Mass Intensity Is Used in the Pharmaceutical Industry To Drive More Sustainable Processes
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