1. Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School University of Bristol Bristol UK
2. Department of Oncology and Metabolism and Insigneo Institute for in silico Medicine University of Sheffield Sheffield UK
3. Department of Trauma and Orthopaedics, Bristol Royal Infirmary University Hospitals Bristol NHS Foundation Trust Bristol UK
4. Bristol Medical School University of Bristol Bristol UK
5. National Institute for Health Research Bristol Biomedical Research Centre University Hospitals Bristol NHS Foundation Trust and University of Bristol Bristol UK