Total Glucosides of Peony Alleviate Joint Destruction in Rabbits With Osteoarthritis

Author:

Chao Wei Chen1ORCID,Yi Shan Ding2,Fei Yue Li3,Tian You Fan1

Affiliation:

1. Department of Orthopaedics and Traumatology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of TCM, Shanghai,  China

2. Kuitun Hospital of Traditional Chinese Medicine of the 7th Division of the Xinjiang Production and Construction Corps, Xinjiang, China

3. Department of Traumatology, Rui Jin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China

Abstract

Objective Although many painkillers can be used to relieve the symptoms of osteoarthritis (OA), these drugs do not address joint bone degeneration and muscle wasting, highlighting the need for alternative treatments. This study evaluated the ability of various plant extracts to inhibit joint destruction, focusing on the total glucosides of peony (TGP) obtained from the normal Chinese medication white peony. Methods A rabbit OA model was established by anterior cruciate ligament resection (ACLT) and TGP treatment was initiated for 3 months. The morphologies of the skeletal muscle fibers, articular cartilage, and subchondral bone of the knee joint were histologically observed via X-ray and micro-computed tomography scan. Results TGP significantly reduced the histopathological changes associated with skeletal muscle atrophy and inflammation, and alleviated cartilage degeneration. In addition, TGP treatment significantly improved the bone density and microstructure of subchondral bone in rabbit knee joints compared with the model group. Conclusion The results suggested that TGP treatment may alleviate the progression of osteoarthritis and reduce the destruction of joint cartilage and bone in ACLT.

Funder

the National Natural Science Foundation of China

the Shanghai Science and Technology Commission

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

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