Glucose monitoring and adaptive feeding of mammalian cell culture in the presence of strong autofluorescence by near infrared Raman spectroscopy
Author:
Affiliation:
1. Biogen, Inc., Engineering and Technology 5000 Davis Dr, Durham, NC, 27709
Publisher
Wiley
Subject
Biotechnology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/btpr.2711
Reference16 articles.
1. Closed loop control of lactate concentration in mammalian cell culture by Raman spectroscopy leads to improved cell density, viability, and biopharmaceutical protein production
2. Quick generation of Raman spectroscopy based in-process glucose control to influence biopharmaceutical protein product quality during mammalian cell culture
3. Cross-scale predictive modeling of CHO cell culture growth and metabolites using Raman spectroscopy and multivariate analysis
4. Generic Raman-based calibration models enabling real-time monitoring of cell culture bioreactors
5. Application of spectroscopic methods for monitoring of bioprocesses and the implications for the manufacture of biologics
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