Closed loop control of lactate concentration in mammalian cell culture by Raman spectroscopy leads to improved cell density, viability, and biopharmaceutical protein production-Reference-Cited by-同舟云学术

Closed loop control of lactate concentration in mammalian cell culture by Raman spectroscopy leads to improved cell density, viability, and biopharmaceutical protein production

Published:2016-06-09 Issue:11 Volume:113 Page:2416-2424
ISSN:0006-3592
Container-title:Biotechnology and Bioengineering
language:en
Short-container-title:Biotechnol. Bioeng.

Author:

Matthews Thomas E.¹,Berry Brandon N.²,Smelko John¹,Moretto Justin¹,Moore Brandon¹,Wiltberger Kelly³

Affiliation:

1. Cell Culture Development; Biogen, Inc.; 5000 Davis Drive Research Triangle Park 27709 North Carolina

2. Cell Culture Development; Biogen, Inc.; Cambridge Massachusetts

3. Manufacturing, Biogen Inc.; Research Triangle Park North Carolina

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

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3. Considerations on the lactate consumption by CHO cells in the presence of galactose;Altamirano;J Biotechnol,2006

4. In-line and real-time prediction of recombinant antibody titer by in situ Raman spectroscopy;André;Anal Chim Acta,2015

5. The challenge of applying Raman spectroscopy to monitor recombinant antibody production;Ashton;Analyst,2013

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