Stable warfarin dose prediction in sub‐Saharan African patients: A machine‐learning approach and external validation of a clinical dose–initiation algorithm

Author:

Asiimwe Innocent G.1ORCID,Blockman Marc2,Cohen Karen2,Cupido Clint34,Hutchinson Claire1,Jacobson Barry5,Lamorde Mohammed6,Morgan Jennie7,Mouton Johannes P.2,Nakagaayi Doreen8ORCID,Okello Emmy8,Schapkaitz Elise9,Sekaggya‐Wiltshire Christine6,Semakula Jerome R.6,Waitt Catriona16,Zhang Eunice J.1,Jorgensen Andrea L.10,Pirmohamed Munir1ORCID

Affiliation:

1. Department of Pharmacology and Therapeutics The Wolfson Centre for Personalized Medicine Medical Research Council Centre for Drug Safety Science Institute of Systems, Molecular and Integrative Biology University of Liverpool Liverpool UK

2. Division of Clinical Pharmacology Department of Medicine University of Cape Town Cape Town South Africa

3. Victoria Hospital Internal Medicine Research Initiative Victoria Hospital Wynberg Cape Town South Africa

4. Department of Medicine University of Cape Town Cape Town South Africa

5. Department of Molecular Medicine and Haematology University of the Witwatersrand Johannesburg South Africa

6. Infectious Diseases Institute Makerere University College of Health Sciences Kampala Uganda

7. Metro District Health Services Western Cape Department of Health Cape Town South Africa

8. Uganda Heart Institute Kampala Uganda

9. Department of Molecular Medicine and Hematology Charlotte Maxeke Johannesburg Academic Hospital National Health Laboratory System Complex and University of Witwatersrand Johannesburg South Africa

10. Department of Health Data Science Institute of Population Health Sciences University of Liverpool Liverpool UK

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

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