Unraveling pleiotropic effects of rifampicin by using physiologically based pharmacokinetic modeling: Assessing the induction magnitude of P‐glycoprotein–cytochrome P450 3A4 dual substrates-Reference-Cited by-同舟云学术

Unraveling pleiotropic effects of rifampicin by using physiologically based pharmacokinetic modeling: Assessing the induction magnitude of P‐glycoprotein–cytochrome P450 3A4 dual substrates

Published:2021-11-02 Issue:12 Volume:10 Page:1485-1496
ISSN:2163-8306
Container-title:CPT: Pharmacometrics & Systems Pharmacology
language:en
Short-container-title:CPT Pharmacom & Syst Pharma

Author:

Pan Xian¹^ORCID,Yamazaki Shinji²^ORCID,Neuhoff Sibylle¹^ORCID,Zhang Mian¹^ORCID,Pilla Reddy Venkatesh³⁴^ORCID

Affiliation:

1. Simcyp Division Certara UK Limited Sheffield UK

2. Pharmacokinetics, Dynamics & Metabolism Pfizer Worldwide Research & Development San Diego California USA

3. Modelling and Simulation, Early Oncolog, Oncology R&D AstraZeneca Cambridge UK

4. Clinical Pharmacology and Pharmacometrics, Biopharmaceuticals R&D AstraZeneca Cambridge UK

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.12717

Reference50 articles.

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4. PBPK modeling to predict drug‐drug interactions of ivosidenib as a perpetrator in cancer patients and qualification of the Simcyp platform for CYP3A4 induction

5. Physiologically‐Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug–Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations

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