Physiologically‐Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug–Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations-Reference-Cited by-同舟云学术

Physiologically‐Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug–Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations

Published:2019-12-31 Issue:5 Volume:107 Page:1082-1115
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin. Pharmacol. Ther.

Author:

Taskar Kunal S.¹,Pilla Reddy Venkatesh²,Burt Howard³,Posada Maria M.⁴,Varma Manthena⁵,Zheng Ming⁶,Ullah Mohammed⁷,Emami Riedmaier Arian⁸,Umehara Ken‐ichi⁷,Snoeys Jan⁹,Nakakariya Masanori¹⁰,Chu Xiaoyan¹¹,Beneton Maud¹²,Chen Yuan¹³,Huth Felix¹⁴,Narayanan Rangaraj¹⁵,Mukherjee Dwaipayan⁸,Dixit Vaishali¹⁶,Sugiyama Yuichi¹⁷,Neuhoff Sibylle³

Affiliation:

1. GlaxoSmithKline DMPK In Vitro In Vivo Translation GSK R&D Ware UK

2. AstraZeneca, Modelling and Simulation Early Oncology DMPK Oncology R&D AstraZeneca Cambridge UK

3. Simcyp‐Division Certara UK Ltd. Sheffield UK

4. Eli Lilly & Company Indianapolis Indiana USA

5. Pfizer Inc. Groton Connecticut USA

6. Bristol-Myers Squibb Company Princeton New Jersey USA

7. Roche Innovation Center Basel Switzerland

8. AbbVie Inc. North Chicago Illinois USA

9. Janssen Research and Development Beerse Belgium

10. Takeda Pharmaceutical Company Ltd. Kanagawa Japan

11. Merck Sharp & Dohme Corp. Kenilworth New Jersey USA

12. Servier Centre-Val de Loire France

13. Genentech San Francisco California USA

14. Novartis Basel Switzerland

15. Shire Lexington Massachusetts USA

16. Eisai Inc. Woodliff Lake New Jersey USA

17. Sugiyama Laboratory Riken Yokohama Japan

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.1693

Reference106 articles.

1. Membrane transporters in drug development

2. US Food and Drug Administration.In Vitro Metabolism‐ and Transporter‐Mediated Drug‐Drug Interaction Studies – Guidance for Industry (Draft Guidance)(2017).

3. The Application of Physiologically Based Pharmacokinetic Modeling to Predict the Role of Drug Transporters: Scientific and Regulatory Perspectives

4. Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS)

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