The vaccine adjuvant alum inhibits IL-12 by promoting PI3 kinase signaling while chitosan does not inhibit IL-12 and enhances Th1 and Th17 responses-Reference-Cited by-同舟云学术

The vaccine adjuvant alum inhibits IL-12 by promoting PI3 kinase signaling while chitosan does not inhibit IL-12 and enhances Th1 and Th17 responses

Published:2012-08-06 Issue:10 Volume:42 Page:2709-2719
ISSN:0014-2980
Container-title:European Journal of Immunology
language:en
Short-container-title:Eur. J. Immunol

Author:

Mori Andres¹,Oleszycka Ewa¹,Sharp Fiona A.¹,Coleman Michelle¹,Ozasa Yuki¹,Singh Manmohan²,O'Hagan Derek T.²,Tajber Lidia³,Corrigan Owen I.³,McNeela Edel A.¹,Lavelle Ed C.¹

Affiliation:

1. Adjuvant Research Group; School of Biochemistry and Immunology; Trinity Biomedical Sciences Institute; Trinity College Dublin; Dublin; Ireland

2. Novartis Vaccines; Cambridge; MA; USA

3. School of Pharmacy and Pharmaceutical Sciences; Trinity College Dublin; Dublin; Ireland

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/eji.201242372/fullpdf

Reference44 articles.

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5. Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants;Eisenbarth;Nature,2008

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