Role of NLRP3 inflammasome in nanoparticle adjuvant-mediated immune response

Author:

Ahmed Momitul1,Kurungottu Pavithra2ORCID,Swetha K.2ORCID,Atla Sandeep3ORCID,Ashok Nivethitha2ORCID,Nagamalleswari Easa4ORCID,Bonam Srinivasa Reddy5ORCID,Sahu Bidya Dhar1ORCID,Kurapati Rajendra2ORCID

Affiliation:

1. Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Guwahati 781101, India

2. School of Chemistry, Indian Institute of Science Education and Research, Thiruvananthapuram 695551, India

3. Texas A&M Drug Discovery Center, Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA

4. MTCC and Gene Bank, CSIR-Institute of Microbial Technology, Sector 39A, Chandigarh, 160036, India

5. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA

Abstract

The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome is pivotal in orchestrating the immune response induced by most of the nanoparticle adjuvants.

Funder

Department of Biotechnology, Ministry of Science and Technology

Science and Engineering Research Board

Department of Science and Technology, Ministry of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

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