Overcoming the Lack of Oral Availability of Cyclic Hexapeptides: Design of a Selective and Orally Available Ligand for the Integrin αvβ3

Author:

Weinmüller Michael1,Rechenmacher Florian1,Kiran Marelli Udaya2,Reichart Florian1,Kapp Tobias G.1,Räder Andreas F. B.1,Di Leva Francesco Saverio3,Marinelli Luciana3,Novellino Ettore3,Muñoz-Félix José M.4,Hodivala-Dilke Kairbaan4,Schumacher Adi5,Fanous Joseph5,Gilon Chaim5,Hoffman Amnon5,Kessler Horst1ORCID

Affiliation:

1. Institute for Advanced Study and Center of Integrated Protein Science; Department Chemie; Technische Universität München; Lichtenbergstrasse 4 85748 Garching Germany

2. Central NMR Facility and Division of Organic Chemistry; CSIR-National Chemical Laboratory; Pune India

3. Dipartimento di Farmacia; Università di Napoli Federico II; Napoli Italy

4. Centre for Tumour Biology; Barts Cancer Institute, -; Queen Mary University of London; John Vane Science Centre; Londonn UK

5. Institutes of Chemistry and Drug Research; The Hebrew University of Jerusalem; Israel

Funder

Deutsche Forschungsgemeinschaft

Worldwide Cancer Research

Cancer Research UK

MIUR-PRIN 2015

Publisher

Wiley

Subject

General Chemistry,Catalysis

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