Tailored Peptide Phenyl Esters Block ClpXP Proteolysis by an Unusual Breakdown into a Heptamer–Hexamer Assembly-Reference-Cited by-同舟云学术

Tailored Peptide Phenyl Esters Block ClpXP Proteolysis by an Unusual Breakdown into a Heptamer–Hexamer Assembly

Published:2019-05-20 Issue:21 Volume:58 Page:7127-7132
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew. Chem. Int. Ed.

Author:

Lakemeyer Markus¹^ORCID,Bertosin Eva²,Möller Friederike³,Balogh Dóra¹^ORCID,Strasser Ralf³,Dietz Hendrik²,Sieber Stephan A.¹^ORCID

Affiliation:

1. Center for Integrated Protein Science (CIPS^M) at theDepartment of ChemistryTechnische Universität München Lichtenbergstr. 4 85747 Garching Germany

2. Physics Department and Institute for Advanced StudyTechnische Universität München Am Coulombwall 4a 85748 Garching Germany

3. Dynamic Biosensors GmbH Lochhamerstr. 15 82152 Planegg Germany

Funder

Deutsche Forschungsgemeinschaft

Studienstiftung des Deutschen Volkes

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201901056

Reference27 articles.

1. Clp chaperones and proteases are central in stress survival, virulence and antibiotic resistance of Staphylococcus aureus

2. ClpXP, an ATP-powered unfolding and protein-degradation machine

3. The Role of ClpP Protease in Bacterial Pathogenesis and Human Diseases

4. α-Amino Diphenyl Phosphonates as Novel Inhibitors of Escherichia coli ClpP Protease

5. Suppression of Staphylococcus aureus virulence by a small-molecule compound

Cited by 11 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Chemical tools to expand the ligandable proteome: diversity-oriented synthesis-based photoreactive stereoprobes;2024-02-29

2. ClpP inhibitors are produced by a widespread family of bacterial gene clusters;Nature Microbiology;2022-03-04

3. Recent advances in Clp protease modulation to address virulence, resistance and persistence of MRSA infection;Drug Discovery Today;2021-09

4. Small molecule inhibitors of the mitochondrial ClpXP protease possess cytostatic potential and re-sensitize chemo-resistant cancers;Scientific Reports;2021-05-27

5. Global Inventory of ClpP- and ClpX-Regulated Proteins in Staphylococcus aureus;Journal of Proteome Research;2020-11-19