Phosphorylation of RAF Kinase Dimers Drives Conformational Changes that Facilitate Transactivation-Reference-Cited by-同舟云学术

Phosphorylation of RAF Kinase Dimers Drives Conformational Changes that Facilitate Transactivation

Published:2015-12-08 Issue:3 Volume:55 Page:983-986
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew. Chem. Int. Ed.

Author:

Jambrina Pablo G.¹,Rauch Nora²^ORCID,Pilkington Ruth²,Rybakova Katja²,Nguyen Lan K.³⁴,Kholodenko Boris N.²,Buchete Nicolae-Viorel⁵^ORCID,Kolch Walter²⁶,Rosta Edina¹^ORCID

Affiliation:

1. Department of Chemistry; King's College London; London SE1 1DB UK

2. Systems Biology Ireland and Conway Institute; University College Dublin, Belfield; Dublin 4 Ireland

3. Systems Biology Ireland; University College Dublin, Belfield; Dublin 4 Ireland

4. Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute; Monash University; Melbourne Victoria 3800 Australia

5. School of Physics and Complex and Adaptative Systems Laboratory; University College Dublin, Belfield; Dublin 4 Ireland

6. School of Medicine & Medical Sciences; University College Dublin, Belfield; Dublin 4 Ireland

Funder

EPSRC

Science Foundation Ireland

European Union

FP7 PRIMES

SynSignal

BBSRC

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/anie.201509272/fullpdf

Reference39 articles.

1. Raf Family Kinases: Old Dogs Have Learned New Tricks

2. Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

3. Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF

4. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

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