RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth-Reference-Cited by-同舟云学术

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

Published:2010-02-03 Issue:7287 Volume:464 Page:431-435
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Hatzivassiliou Georgia,Song Kyung,Yen Ivana,Brandhuber Barbara J.,Anderson Daniel J.,Alvarado Ryan,Ludlam Mary J. C.,Stokoe David,Gloor Susan L.,Vigers Guy,Morales Tony,Aliagas Ignacio,Liu Bonnie,Sideris Steve,Hoeflich Klaus P.,Jaiswal Bijay S.,Seshagiri Somasekar,Koeppen Hartmut,Belvin Marcia,Friedman Lori S.,Malek Shiva

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/nature08833.pdf

Reference33 articles.

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2. Yeh, J. J. et al. KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer. Mol. Cancer Ther. 8, 834–843 (2009)

3. Hoeflich, K. P. et al. Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression. Cancer Res. 69, 3042–3051 (2009)

4. Hansen, J. D. et al. Potent and selective pyrazole-based inhibitors of B-Raf kinase. Bioorg. Med. Chem. Lett. 18, 4692–4695 (2008)

5. Tsai, J. et al. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proc. Natl Acad. Sci. USA 105, 3041–3046 (2008)

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