Discovery of an MLLT1/3 YEATS Domain Chemical Probe-Reference-Cited by-同舟云学术

Discovery of an MLLT1/3 YEATS Domain Chemical Probe

Published:2018-11-16 Issue:50 Volume:57 Page:16302-16307
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew. Chem. Int. Ed.

Author:

Moustakim Moses¹²,Christott Thomas¹,Monteiro Octovia P.¹,Bennett James¹,Giroud Charline¹,Ward Jennifer¹,Rogers Catherine M.¹,Smith Paul¹,Panagakou Ioanna¹,Díaz-Sáez Laura¹,Felce Suet Ling³,Gamble Vicki³,Gileadi Carina³,Halidi Nadia³,Heidenreich David⁴,Chaikuad Apirat¹⁴,Knapp Stefan¹⁴,Huber Kilian V. M.¹,Farnie Gillian³,Heer Jag⁵,Manevski Nenad⁵,Poda Gennady⁶⁷,Al-awar Rima⁶⁸,Dixon Darren J.²,Brennan Paul E.¹⁹^ORCID,Fedorov Oleg¹

Affiliation:

1. Structural Genomics Consortium & Target Discovery Institute; University of Oxford, NDMRB; Old Road Campus Oxford, OX3 7DQ & OX3 7FZ UK

2. Department of Chemistry; University of Oxford; Chemistry Research Laboratory; Mansfield Road Oxford OX1 3TA UK

3. Structural Genomics Consortium & Botnar Research Centre; University of Oxford; Windmill Road Oxford OX3 7LD UK

4. Institute for Pharmaceutical Chemistry and Buchmann Institute for Life Sciences; Johann Wolfgang Goethe-University; 60438 Frankfurt am Main Germany

5. UCB Pharma Ltd; Slough SL1 3WE UK

6. Drug Discovery Program; Ontario Institute for Cancer Research; Toronto ON Canada

7. Leslie Dan Faculty of Pharmacy; University of Toronto; Toronto ON Canada

8. Department of Pharmacology and Toxicology; University of Toronto; Toronto ON Canada

9. Alzheimer's Research (UK) Oxford Drug Discovery Institute; Nuffield Department of Medicine; University of Oxford; NDM Research Building; Roosevelt Drive Oxford OX3 7FZ UK

Funder

Wellcome Trust

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/anie.201810617/fullpdf

Reference32 articles.

1. Targeting bromodomains: epigenetic readers of lysine acetylation

2. Lateral Thinking: How Histone Modifications Regulate Gene Expression

3. Chemical probes and inhibitors of bromodomains outside the BET family