Process intensification to produce a difficult‐to‐express therapeutic enzyme by high cell density perfusion or enhanced fed‐batch-Reference-Cited by-同舟云学术

Process intensification to produce a difficult‐to‐express therapeutic enzyme by high cell density perfusion or enhanced fed‐batch

Published:2021-05-13 Issue:9 Volume:118 Page:3533-3544
ISSN:0006-3592
Container-title:Biotechnology and Bioengineering
language:en
Short-container-title:Biotechnol Bioeng

Author:

Särnlund Sigrid¹²³^ORCID,Jiang Yun¹^ORCID,Chotteau Veronique²³^ORCID

Affiliation:

1. Manufacturing Science and Technology, Swedish Orphan Biovitrum Solna Sweden

2. AdBIOPRO, Competence Centre for Advanced Bioproduction by Continuous Processing Stockholm Sweden

3. Department of Industrial Biotechnology, School of Engineering Sciences in Chemistry, Biotechnology and Health Royal Institute of Technology Stockholm Sweden

Funder

VINNOVA

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bit.27806

Reference24 articles.

1. Upstream process intensification and continuous manufacturing

2. Very high density of Chinese hamster ovary cells in perfusion by alternating tangential flow or tangential flow filtration in WAVE bioreactor™—part II: Applications for antibody production and cryopreservation

3. Very high density of CHO cells in perfusion by ATF or TFF in WAVE bioreactor™. Part I. Effect of the cell density on the process

4. Shift to high‐intensity, low‐volume perfusion cell culture enabling a continuous, integrated bioprocess

5. Identification of cell culture conditions to controlN-glycosylation site-occupancy of recombinant glycoproteins expressed in CHO cells

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