Intensification of bioprocesses – definition, examples, challenges and future directions-Reference-Cited by-同舟云学术

Intensification of bioprocesses – definition, examples, challenges and future directions

Published:2024-02-28 Issue: Volume: Page:
ISSN:2365-6581
Container-title:Physical Sciences Reviews
language:en
Short-container-title:

Author:

Hartmann Lukas¹,Krieg Thomas²,Holtmann Dirk¹

Affiliation:

1. Institute of Process Engineering in Life Sciences , 150232 Karlsruhe Institute of Technology , Fritz-Haber-Weg 4 , 76131 Karlsruhe , Germany

2. 84647 HP BioP Launch & Innovation, Boehringer Ingelheim Pharma GmbH & Co. KG , Biberach a.d. Riß , Germany

Abstract

Abstract Strategies to reduce cost and emission profiles are becoming increasingly important for the development of affordable and sustainable bio-based production. The overall objective of process intensification in different industries is to achieve substantial benefits in terms of cost, product concentration and quality, while eliminating waste and improving process safety. Intensification of bioprocesses could be a valuable tool for enhancing the efficiency and reducing resource consumption in bioproduction. In general, bioprocess intensification is defined as an increase in bioproduct output relative to cell concentration, time, reactor volume or cost. This brief overview provides a definition of process intensification in biotechnology, presents several general and specific examples, and addresses some of the current challenges.

Publisher

Walter de Gruyter GmbH

Link

https://www.degruyter.com/document/doi/10.1515/psr-2022-0101/pdf

Reference169 articles.

1. Stankiewicz, A, Moulijn, JA. Process intensification: transforming chemical engineering. Chem Eng Prog 2000;96:22–33.

2. Van Gerven, T, Stankiewicz, A. Structure, energy, synergy, time – the fundamentals of process intensification. Ind Eng Chem Res 2009;48:2465–74. https://doi.org/10.1021/ie801501y.

3. Burek, BO, Dawood, AWH, Hollmann, F, Liese, A, Holtmann, D. Process intensification as game changer in enzyme catalysis. Front Catal 2022;2:1–18. https://doi.org/10.3389/fctls.2022.858706.

4. García-Molina, G, Natale, P, Coito, AM, Cava, DG, A. C. Pereira, I, López-Montero, I, et al.. Electro-enzymatic ATP regeneration coupled to biocatalytic phosphorylation reactions. Bioelectrochemistry 2023;152:108432. https://doi.org/10.1016/j.bioelechem.2023.108432.

5. Jack, J, Fu, H, Leininger, A, Hyster, TK, Ren, ZJ. Cell-free CO2 valorization to C6 pharmaceutical precursors via a novel electro-enzymatic process. ACS Sustain Chem Eng 2022;10:4114–21. https://doi.org/10.1021/acssuschemeng.1c06746.