Affiliation:
1. College of Chemical Engineering Qingdao University of Science and Technology Qingdao 266042 P. R. China
2. Key Lab of Biobased Polymer Materials of Shandong Provincial Education Department College of Polymer Science and Engineering Qingdao University of Science and Technology Qingdao 266042 P. R. China
3. National Engineering Laboratory of Medical Implantable Devices & Key Laboratory for Medical Implantable Devices of Shandong Province, WEGO Holding Company Limited Weihai 264210 P. R. China
Abstract
AbstractAbdominal wall defect caused by surgical trauma, congenital rupture, or tumor resection may result in hernia formation or even death. Tension‐free abdominal wall defect repair by using patches is the gold standard to solve such problems. However, adhesions following patch implantation remain one of the most challenging issues in surgical practice. The development of new kinds of barriers is key to addressing peritoneal adhesions and repairing abdominal wall defects. It is already well recognized that ideal barrier materials need to have good resistance to nonspecific protein adsorption, cell adhesion, and bacterial colonization for preventing the initial development of adhesion. Herein, electrospun poly(4‐hydroxybutyrate) (P4HB) membranes infused with perfluorocarbon oil are used as physical barriers. The oil‐infused P4HB membranes can greatly prevent protein attachment and reduce blood cell adhesion in vitro. It is further shown that the perfluorocarbon oil‐infused P4HB membranes can reduce bacterial colonization. The in vivo study reveals that perfluoro(decahydronaphthalene)‐infused P4HB membranes can significantly prevent peritoneal adhesions in the classic abdominal wall defects’ model and accelerate defect repair, as evidenced by gross examination and histological evaluation. This work provides a safe fluorinated lubricant‐impregnated P4HB physical barrier to inhibit the formation of postoperative peritoneal adhesions and efficiently repair soft‐tissue defects.
Funder
National Natural Science Foundation of China
Subject
Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering,Biotechnology
Cited by
2 articles.
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