Direct and metabolism-dependent cytochrome P450 inhibition assays for evaluating drug-drug interactions
Author:
Affiliation:
1. College of Pharmacy and RCTCP; Chungnam National University; Daejeon; 305-764; Republic of Korea
Publisher
Wiley
Subject
Toxicology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/jat.1720/fullpdf
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3. Application of a generic fast gradient liquid chromatography tandem mass spectrometry method for the analysis of cytochrome P450 probe substrates;Ayrton;Rapid Commun. Mass Spectrom.,1998
4. An examination of IC50 and IC50-shift experiments in assessing time-dependent inhibition of CYP3A4, CYP2D6 and CYP2 C9 in human liver microsomes;Berry;Drug Metab. Lett.,2008
5. Fluvoxamine is a potent inhibitor of cytochrome P4501A2;Brøsen;Biochem. Pharmacol.,1993
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