S ‐adenosylmethionine and methylthioadenosine boost cellular productivities of antibody forming Chinese hamster ovary cells
Author:
Affiliation:
1. Institute of Biochemical Engineering University of Stuttgart, Allmandring Stuttgart Germany
2. Xell AG Bielefeld Germany
3. Evonik Nutrition & Care GmbH Darmstadt Germany
4. Boehringer Ingelheim Pharma GmbH & Co. KG Biberach Germany
Funder
Bundesministerium für Bildung und Forschung
Publisher
Wiley
Subject
Applied Microbiology and Biotechnology,Bioengineering,Biotechnology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/bit.27484
Reference50 articles.
1. Regulation of protein secretion in Chinese hamster ovary cells by cell cycle position and cell density *1Plasminogen activator, procollagen and fibronectin
2. The Organization of Replicon Clusters Is Not Affected by Polyamine Depletion
3. Mechanisms and kinetics of monoclonal antibody synthesis and secretion in synchronous and asynchronous hybridoma cell cultures
4. S-adenosylmethionine and methylthioadenosine are antiapoptotic in cultured rat hepatocytes but proapoptotic in human hepatoma cells
5. Perfusion cultures require optimum respiratory ATP supply to maximize cell‐specific and volumetric productivities
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1. A Metabolomics Approach to Increasing Chinese Hamster Ovary (CHO) Cell Productivity;Metabolites;2021-11-30
2. Compartment‐specific 13 C metabolic flux analysis reveals boosted NADPH availability coinciding with increased cell‐specific productivity for IgG1 producing CHO cells after MTA treatment;Engineering in Life Sciences;2021-11-09
3. Compartment-specific metabolome labeling enables the identification of subcellular fluxes that may serve as promising metabolic engineering targets in CHO cells;Bioprocess and Biosystems Engineering;2021-09-30
4. Methylthioadenosine (MTA) boosts cell‐specific productivities of Chinese hamster ovary cultures: dosage effects on proliferation, cell cycle and gene expression;FEBS Open Bio;2020-11-11
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