A novel bioanalytical method based on UHPLC-HRMS/MS for the quantification of oleuropein in human serum. Application to a pharmacokinetic study

Author:

Lemonakis Nikolaos1,Mougios Vassilis2,Halabalaki Maria1,Skaltsounis Alexios- Leandros1,Gikas Evagelos3

Affiliation:

1. Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy; National and Kapodistrian University of Athens; Panepistimiopoli Zografou 15771 Athens Greece

2. School of Physical Education and Sports Science; Aristotle University of Thessaloniki; 54124 Thessaloniki Greece

3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy; National and Kapodistrian University of Athens, Panepistimiopolis Zografou; 15771 Athens Greece

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference38 articles.

1. The olive constituent oleuropein exhibits anti-ischemic, antioxidative, and hypolipidemic effects in anesthetized rabbits;Andreadou;The Journal of Nutrition,2006

2. Rapid quantitative determination of oleuropein in olive leaves (Olea europaea) using mid-infrared spectroscopy combined with chemometric analyses;Aouidi;Industrial Crops and Products,2012

3. Analysis of phenolic compounds in extra virgin olive oil by using reversed-phase capillary electrochromatography;Aturki;Electrophoresis,2008

4. Simultaneous quantification of oleuropein and its metabolites in rat plasma by liquid chromatography electrospray ionization tandem mass spectrometry;Bazoti;Biomedical Chromatography,2010

5. Human absorption and metabolism of oleuropein and hydroxytyrosol ingested as olive (Olea europaea L.) leaf extract;Bock;Molecular Nutrition and Food Research,2013

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